CIDEA antibody (AA 200-214)

Catalog No. ABIN1886853

This anti-CIDEA antibody is a Rabbit Polyclonal antibody detecting CIDEA in WB, ELISA and IHC. Suitable for Mouse.

Quick Overview for CIDEA antibody (AA 200-214) (ABIN1886853)

Target: CIDEA (Cell Death-Inducing DFFA-Like Effector A (CIDEA))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CIDEA antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-CIDEA Antibody

Binding Specificity: AA 200-214

Cross-Reactivity (Details): It has no cross activity to CIDE-B.

Purification: Affinity chromatography purified via peptide column

Immunogen: Peptide corresponding to amino acids 200 to 214 of mouse CIDE-A.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for CIDEA

Target: CIDEA (Cell Death-Inducing DFFA-Like Effector A (CIDEA))

Alternative Name: CIDE-A

Background: Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands.Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases.These death signals finally cause the degradation of chromosomal DNA by activated DNase.DFF45/ICAD has been identified as inhibitor of caspase activated DNase DFF40/CAD.DFF45 related proteins CIDE-A and CIDE-B (for cell death-inducing DFF-like effector A and B) were recently identified.CIDE contains a new type of domain termed CIDE-N, which has high homology with the regulatory domains of DFF45/ICAD and DFF40/CAD.Expression of CIDE-A induces DNA fragmentation and activates apoptosis, which is inhibited by DFF45.CIDE-A is a DFF45-inhibitable effector that promotes cell death and DNA fragmentation.CIDE-A is expressed in many tissues.

Molecular Weight: 25 kDa